中国DOS联盟

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BASIC-PATENT:

UNITED STATES OF AMERICA (US)

PATENT (Number; Kind; Date): United States of America (US) 5,958,446; A; September 28, 1999

TITLE: SOLUBILITY PARAMETER BASED DRUG DELIVERY SYSTEM AND METHOD FOR ALTERING DRUG SATURATION CONCENTRATION
INVENTOR: MIRANDA JESUS, United States of America (US); SABLOTSKY STEVEN, United States of America (US)
PRIORITY (Number; Kind; Date):
United States of America (US) 1995-433754; A; May 04, 1995
United States of America (US) 1991-722342; A1; June 27, 1991
United States of America (US) 1989-295847; A2; January 11, 1989
United States of America (US) 1988-164482; A2; March 04, 1988
United States of America (US) 1991-671709; A2; April 02, 1991
World Intellectual Property Organisation (WO) 1990US9001750; W; March 28, 1990
PATENT ASSIGNEE: NOVEN PHARMA, United States of America (US)
APPLICATION (Number; Kind; Date): United States of America (US) 1995433754; A; May 04, 1995
INT-CL: A61F13/02 (Section A, Class 61, Sub-class F, Group 13, Sub-group 02)


NAT-CL: 424448; X426449
EURO-CL: A61F13/02M; A61K9/70E; A61L15/18; A61L15/58; A61L15/58M+C08L33/00; A61L15/58M+C08L31/04
DERWENT NUMBER: C1989-106432; C1990-225696; C1991-230072; C1991-310376; C1993-036110; C1994-109332; C1995-044946; C1997-558092
CHEMICAL ABSTRACT NUMBER: 111(10)084137W; 114(04)030158X; 116(10)091389M; 118(16)154566F; 120(26)331144F; 128(15)184708C
ABST:
The method of adjusting the saturation concentration of a drug in a transdermal composition for application to the dermis, which comprises mixing polymers having differing solubility parameters, so as to modulate the delivery of the drug. This results in the ability to achieve a predetermined permeation rate of the drug into and through the dermis. In one embodiment, a dermal composition of the present invention comprises a drug, an acrylate polymer, and a polysiloxane. The dermal compositions can be produced by a variety of methods known in the preparation of drug-containing adhesive preparations, including the mixing of the polymers, drug, and additional ingredients in solution, followed by removal of the processing solvents. The method and composition of this invention permit selectable loading of the drug into the dermal formulation and adjustment of the delivery rate of the drug from the composition through the dermis, while maintaining acceptable shear, tack, and peel adhesive properties.

PATENT (Number; Kind; Date): United States of America (US) 5,300,291; A; April 05, 1994

PATENT (Number; Kind; Date): World Intellectual Property Organisation (WO) 9,640,086; A3; February 13, 1997

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